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Epithalon (Epitalon, Ala-Glu-Asp-Gly) is a synthetic tetrapeptide studied in telomerase, pineal function, and cell aging research.
Epithalon, also spelled Epitalon, is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly. Vladimir Khavinson and colleagues in St. Petersburg developed it as a synthetic counterpart to epithalamin, a polypeptide extract of the pineal gland. Its four-residue length places it among the simplest bioregulatory peptides studied.
Khavinson’s group proposed that short peptides can interact with DNA and chromatin to influence gene expression, a concept they called peptide bioregulation. The tetrapeptide was designed after analysis of the amino acid composition of epithalamin, and it became the most widely cited example of this idea. In cultured human fibroblasts, researchers reported induction of telomerase activity and elongation of telomeres. Other studies examined its influence on melatonin secretion in aged animals, on antioxidant enzyme activity, and on spontaneous tumor incidence and lifespan in rodents and fruit flies.
Much of this literature comes from a single research school, and independent replication is limited. For that reason, Epithalon is a common subject for laboratories aiming to test published findings on telomere biology and pineal function under controlled conditions.
For research use only. Not for human or veterinary use. Not a drug, food, or cosmetic. Sold to qualified researchers for in-vitro and laboratory research.
| Weight | 10mg, 100mg |
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