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Melatonin (N-acetyl-5-methoxytryptamine) is a pineal indoleamine studied for MT1/MT2 receptor signaling, circadian biology, and antioxidant chemistry in laboratory models.
Melatonin (N-acetyl-5-methoxytryptamine) is an indoleamine hormone produced mainly by the pineal gland. It is a small molecule synthesized from serotonin rather than a peptide, and it appears in this catalog alongside pineal-related research compounds such as Epithalon. This product provides melatonin in 10mg tablets.
Melatonin synthesis follows a two-step pathway from serotonin. Arylalkylamine N-acetyltransferase (AANAT) converts serotonin to N-acetylserotonin, and acetylserotonin O-methyltransferase (ASMT) then produces melatonin. AANAT activity rises in darkness under control of the suprachiasmatic nucleus, so circulating melatonin follows a daily rhythm.
Melatonin acts through two G protein-coupled receptors, MT1 and MT2, which are expressed in the brain, retina, and many peripheral tissues. Separately from receptor signaling, it scavenges reactive oxygen and nitrogen species in cell-free and cell culture systems, and several of its metabolites share this property. Animal research has investigated its role in circadian entrainment, seasonal reproduction in photoperiodic species, and mitochondrial function. Its small, amphiphilic structure lets it cross cell membranes readily, and it has been detected in organisms ranging from bacteria and plants to mammals. Laboratories working on pineal peptides often use melatonin as a reference compound or measured endpoint.
For research use only. Not for human or veterinary use. Not a drug, food, or cosmetic. Sold to qualified researchers for in-vitro and laboratory research.
| Weight | 10mg |
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