Melanotan 1 HA – 10mg

Description

Melanotan I, known by the international nonproprietary name afamelanotide, is a synthetic linear analog of alpha-melanocyte-stimulating hormone (α-MSH). It has 13 amino acids and differs from native α-MSH by two substitutions: norleucine at position 4 and D-phenylalanine at position 7. The compound is also written as [Nle4, D-Phe7]-α-MSH or NDP-MSH.

What is Melanotan I?

α-MSH is a cleavage product of proopiomelanocortin (POMC) and binds a family of melanocortin receptors. Melanotan I is a potent agonist of the melanocortin 1 receptor (MC1R), which is expressed on melanocytes and drives eumelanin production through a cAMP-dependent pathway. The two substitutions were introduced by researchers at the University of Arizona to make the peptide more resistant to enzymatic degradation and to prolong receptor activation relative to the native hormone.

Melanotan I is distinct from Melanotan II. Melanotan II is a shorter cyclic peptide with broader activity across melanocortin receptors, including MC3R and MC4R, whereas Melanotan I is linear and was studied mainly for MC1R-mediated pigmentation. Research with afamelanotide has covered melanogenesis in cultured melanocytes, DNA damage responses to ultraviolet exposure, and photobiology in skin models.

Research Applications

• MC1R signaling and the cAMP pathway
• Melanogenesis and eumelanin synthesis in cultured melanocytes
• UV-induced DNA damage models
• Comparative melanocortin receptor pharmacology
• Enzymatic stability of α-MSH analogs

Product Specifications

• Available sizes: 5mg, 10mg
• Form: Lyophilized powder in sealed vial
• Sequence: Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
• Purity: ≥99% (HPLC)
• Storage: Store lyophilized product at -20°C; protect from light

For research use only. Not for human or veterinary use. Not a drug, food, or cosmetic. Sold to qualified researchers for in-vitro and laboratory research.