N-Acetyl Semax Amidate Spray

Description

N-Acetyl Semax Amidate (NA-Semax-Amidate) Spray is a liquid preparation of Semax modified at both termini, with an acetyl group on methionine and an amide group on the final proline. The underlying peptide is the heptapeptide Met-Glu-His-Phe-Pro-Gly-Pro. This listing is the spray format, and the lyophilized vial is sold separately.

What is N-Acetyl Semax Amidate Spray?

Each modification targets a different set of enzymes. The acetyl group blocks the N-terminal amine that aminopeptidases recognize, and C-terminal amidation replaces the carboxyl group that carboxypeptidases act on. Researchers interested in peptide half-life use such dual-capped analogs to test how much stability can be gained over the parent sequence without changing the core residues.

Semax itself has been studied mainly in rats and mice. Published work covers BDNF expression, responses to hypoxia and ischemia, and interactions with melanocortin receptor systems, since the peptide derives from the ACTH sequence. Pre-dissolved spray material lets investigators study the dual-capped molecule in its solution state, including degradation over time at refrigerated temperatures. Because N-Acetyl Semax Spray shares the same acetylated N-terminus, running the two side by side isolates the effect of the C-terminal amide under identical solution conditions.

Research Applications

• Dual-terminal capping and peptide half-life
• Carboxypeptidase and aminopeptidase resistance assays
• Degradation profiling of peptide solutions under refrigeration
• Rodent hypoxia and ischemia models
• Melanocortin receptor-related signaling

Product Specifications

• Available sizes: 20mg, 30mg
• Form: Nasal spray solution (pre-dissolved)
• Sequence: Ac-Met-Glu-His-Phe-Pro-Gly-Pro-NH2
• Purity: ≥99% (HPLC)
• Storage: Refrigerate at 2-8°C; protect from light

For research use only. Not for human or veterinary use. Not a drug, food, or cosmetic. Sold to qualified researchers for in-vitro and laboratory research.