Description
N-Acetyl Semax, sometimes listed as NA-Semax, is the N-terminally acetylated form of Semax, a synthetic seven-amino-acid peptide derived from adrenocorticotropic hormone. It is supplied as a dry lyophilized powder in a sealed vial. Only the N-terminus is modified in this version, so comparison with the parent peptide isolates the effect of a single terminal change.
What is N-Acetyl Semax?
Semax combines the 4-7 fragment of ACTH with a C-terminal Pro-Gly-Pro extension, a motif added to protect the chain from rapid enzymatic cleavage. Work on the parent compound has centered on the central nervous system. Rodent experiments have reported changes in neurotrophin expression, in dopaminergic and serotonergic markers, and in inflammatory gene activity after experimental stroke.
The acetyl cap sits on the N-terminal methionine, while the C-terminal proline remains a free acid, so the molecule has one protected end rather than two. Lyophilized material suits laboratories that want to prepare fresh solutions at a chosen concentration and buffer, and it generally keeps longer in storage than a pre-dissolved product. For work that calls for a ready-made solution, the N-Acetyl Semax Spray listing covers the same molecule in liquid form.
Research Applications
- Neurotrophin (BDNF, NGF) signaling in rodent models
- Monoamine neurotransmitter research
- Inflammatory gene expression after experimental ischemia
- Solubility and stability testing in custom buffers
- Structure-activity comparisons with native Semax
Product Specifications
- Available sizes: 20mg, 30mg
- Form: Lyophilized powder in sealed vial
- Sequence: Ac-Met-Glu-His-Phe-Pro-Gly-Pro
- Purity: ≥99% (HPLC)
- Storage: Store lyophilized product at -20°C; protect from light
For research use only. Not for human or veterinary use. Not a drug, food, or cosmetic. Sold to qualified researchers for in-vitro and laboratory research.






