Original price was: $116.99.$89.99Current price is: $89.99.
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SLU-PP-332 is a small molecule ERR agonist studied as an exercise mimetic in mouse models of muscle metabolism and energy expenditure. Supplied as 60 capsules.
SLU-PP-332 is a synthetic small molecule that activates the estrogen-related receptors (ERRs), a family of orphan nuclear receptors. It is not a peptide. The compound was developed at Saint Louis University, which gives it the SLU prefix, and is described in the literature as a pan-ERR agonist with the highest potency at ERRα.
ERRα, ERRβ, and ERRγ regulate genes involved in mitochondrial biogenesis, oxidative phosphorylation, and fatty acid oxidation. They work closely with the coactivator PGC-1α, a central controller of cellular energy metabolism. Despite the name, ERRs do not bind estrogen. Knockout and overexpression studies in mice have tied ERRα and ERRγ to exercise capacity and to the oxidative profile of muscle and heart tissue, which made the receptors targets for synthetic agonists.
In mouse studies, SLU-PP-332 increased the proportion of oxidative type IIa muscle fibers and extended running endurance, leading researchers to describe it as an exercise mimetic. Follow-up work in mouse models of diet-induced obesity reported higher energy expenditure and fatty acid oxidation, along with reduced fat mass and improved insulin sensitivity in those animals. These findings are limited to rodent and cell studies.
For research use only. Not for human or veterinary use. Not a drug, food, or cosmetic. Sold to qualified researchers for in-vitro and laboratory research.
