Description

Nicotinamide adenine dinucleotide (NAD+) is a coenzyme found in every living cell. It consists of two nucleotides, one carrying adenine and one carrying nicotinamide, joined through their phosphate groups. It is a small molecule, not a peptide.

What is NAD+?

NAD+ has two broad roles. As a redox cofactor it accepts electrons in glycolysis, the TCA cycle and fatty acid oxidation, cycling between NAD+ and NADH. As a consumed substrate it is broken down by sirtuins (protein deacylases), poly(ADP-ribose) polymerases (PARPs) involved in DNA repair, and the NADase CD38. Cells replace it through salvage pathways from nicotinamide, nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN). Rodent studies have reported lower NAD+ levels in several tissues with age, which is why the NAD+ metabolome is a common target in ageing research.

Research Applications

NAD+/NADH redox balance and mitochondrial respiration
Sirtuin and PARP enzyme activity assays
CD38 NADase activity
Salvage pathway flux (NR, NMN, nicotinamide)
Mitochondrial studies alongside MOTS-c and SS-31

Product Specifications

Compound: β-nicotinamide adenine dinucleotide (oxidised form)
Available sizes: 100mg, 500mg
Form: lyophilized powder in a sealed vial
Purity: ≥99% (HPLC), manufactured in the USA
Certificate of Analysis available for each batch
Storage: store lyophilized product at -20°C, protected from light

For research use only. Not for human or veterinary use. Not a drug, food, or cosmetic. Sold to qualified researchers for in-vitro and laboratory research.