N-Acetyl Selank Amidate

Description

N-Acetyl Selank Amidate is Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) with an acetyl group on the N-terminus and an amide in place of the C-terminal carboxylic acid. This listing is the lyophilized powder in a sealed vial, for laboratories that prefer to prepare their own solutions.

What is N-Acetyl Selank Amidate?

Selank is a synthetic heptapeptide developed at the Institute of Molecular Genetics of the Russian Academy of Sciences as an analogue of tuftsin, with a Pro-Gly-Pro tail added to slow enzymatic breakdown. Animal studies of the parent peptide have examined anxiety-related behaviour, GABAergic gene expression and cytokine expression.

Capping both ends blocks the sites that aminopeptidases and carboxypeptidases act on and removes both terminal charges. Researchers use dual-capped analogues to compare stability and membrane behaviour against native Selank. Published literature on the capped form is much thinner than for the parent peptide, which makes it a subject for comparative work rather than a well-characterised tool compound.

Research Applications

• Exopeptidase resistance of dual-capped peptides
• Comparative stability of native, N-acetyl and N-acetyl amidate Selank
• GABAergic and cytokine gene expression in rodent models
• Solubility and buffer compatibility testing

Product Specifications

• Sequence: Ac-Thr-Lys-Pro-Arg-Pro-Gly-Pro-NH2
• Molecular formula: C35H60N12O9, molar mass 792.93 g/mol
• Available sizes: 20mg, 30mg (spray format: N-Acetyl Selank Amidate Spray)
• Form: lyophilized powder in a sealed vial
• Purity: ≥99% (HPLC), manufactured in the USA
• Certificate of Analysis available for each batch
• Storage: store lyophilized product at -20°C, protected from light

For research use only. Not for human or veterinary use. Not a drug, food, or cosmetic. Sold to qualified researchers for in-vitro and laboratory research.