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N-Acetyl Semax Spray

Price range: $46.45 through $70.39

N-Acetyl Semax as a ready-made spray solution. An N-terminally acetylated ACTH(4-10) analog studied for solution stability and BDNF/TrkB expression in rodent models.

Description

N-Acetyl Semax Spray is a pre-mixed solution of Semax that has been acetylated at its N-terminal methionine. Semax is a heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) based on the ACTH(4-10) region of adrenocorticotropic hormone. Unlike the vial version of N-Acetyl Semax, this product arrives in liquid spray format.

What is N-Acetyl Semax Spray?

Semax was designed at the Institute of Molecular Genetics in Moscow by joining the ACTH(4-7) sequence Met-Glu-His-Phe to a Pro-Gly-Pro tripeptide. The resulting molecule does not act as a corticotropin. Rat studies have tracked changes in brain-derived neurotrophic factor (BDNF) and its receptor TrkB in the hippocampus and frontal cortex, along with gene expression shifts in models of focal cerebral ischemia.

Acetylating the N-terminal amine is intended to slow degradation by aminopeptidases, and studies of modified Semax analogs compare their persistence against the native heptapeptide. A spray solution adds another variable of interest: how an acetylated peptide holds up over time once dissolved, compared with lyophilized material that is reconstituted just before an experiment. Pairing it with N-Acetyl Semax Amidate Spray also shows what an added C-terminal amide contributes, since the two share the same acetylated N-terminus.

Research Applications

  • Solution-phase stability of acetylated ACTH fragments
  • BDNF and TrkB expression in rodent brain tissue
  • Transcriptional responses in cerebral ischemia models
  • Structure-activity work on melanocortin-derived peptides
  • Aminopeptidase degradation assays

Product Specifications

  • Available sizes: 20mg, 30mg
  • Form: Nasal spray solution (pre-dissolved)
  • Sequence: Ac-Met-Glu-His-Phe-Pro-Gly-Pro
  • Purity: ≥99% (HPLC)
  • Storage: Refrigerate at 2-8°C; protect from light

For research use only. Not for human or veterinary use. Not a drug, food, or cosmetic. Sold to qualified researchers for in-vitro and laboratory research.

Additional information

Weight

20mg, 30mg