Description
N-Acetyl Semax Spray is a pre-mixed solution of Semax that has been acetylated at its N-terminal methionine. Semax is a heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) based on the ACTH(4-10) region of adrenocorticotropic hormone. Unlike the vial version of N-Acetyl Semax, this product arrives in liquid spray format.
What is N-Acetyl Semax Spray?
Semax was designed at the Institute of Molecular Genetics in Moscow by joining the ACTH(4-7) sequence Met-Glu-His-Phe to a Pro-Gly-Pro tripeptide. The resulting molecule does not act as a corticotropin. Rat studies have tracked changes in brain-derived neurotrophic factor (BDNF) and its receptor TrkB in the hippocampus and frontal cortex, along with gene expression shifts in models of focal cerebral ischemia.
Acetylating the N-terminal amine is intended to slow degradation by aminopeptidases, and studies of modified Semax analogs compare their persistence against the native heptapeptide. A spray solution adds another variable of interest: how an acetylated peptide holds up over time once dissolved, compared with lyophilized material that is reconstituted just before an experiment. Pairing it with N-Acetyl Semax Amidate Spray also shows what an added C-terminal amide contributes, since the two share the same acetylated N-terminus.
Research Applications
- Solution-phase stability of acetylated ACTH fragments
- BDNF and TrkB expression in rodent brain tissue
- Transcriptional responses in cerebral ischemia models
- Structure-activity work on melanocortin-derived peptides
- Aminopeptidase degradation assays
Product Specifications
- Available sizes: 20mg, 30mg
- Form: Nasal spray solution (pre-dissolved)
- Sequence: Ac-Met-Glu-His-Phe-Pro-Gly-Pro
- Purity: ≥99% (HPLC)
- Storage: Refrigerate at 2-8°C; protect from light
For research use only. Not for human or veterinary use. Not a drug, food, or cosmetic. Sold to qualified researchers for in-vitro and laboratory research.





